Relationship between serum vitamin D and forced expiratory volume in patients with chronic obstructive pulmonary disease (COPD)

Authors

  • Mohsen Monadi
  • Alireza Firouzjahi
  • Behzad Heidari
  • Mahmoud Monadi
  • Masumeh Asgharpour
  • Mohammad Ali Ghazi Mirsaied
Abstract:

Background: Vitamin D deficiency seems to be associated with pulmonary function deterioration. The present study was designed to investigate the relationship between serum vitamin D and forced expiratory volume in patients with chronic obstructive pulmonary disease (COPD). Methods: From September 2011 to April 2012 eighty consecutive patients with COPD presented to an outpatient clinic of Babol University- Teaching Hospital entered to the study. Diagnosis of COPD was confirmed according to clinical findings and pulmonary function test. Serum 25-hydroxyvitamin D (25-OHD) was assessed by chemiluminuscence method and postbronchodilator forced expiratory volume in 1s (FEV1) was measured in all patients. The objective of this study was to determine the relationship between serum 25-OHD concentrations and FEV1 value. The patients were classified according to serum 25- OHD concentrations as less 10ng/ml, 10-19.9 20-29.9 30-39.9 and 40ng/ml or higher. The mean values of FEV1 for each class of serum 25-OHD were determined and compared. Results: The mean age of patients was 67.4±11.5 years. The mean FEV1 volume in serum 25-OHD deficient COPD was lower than sufficient COPD (1.550±0.55 vs 1.650±-0.58, p=0.45). Mean FEV1 values increased from 1.55±0.55 L in patients with mean serum 25-OHD 40 ng/ml. There was a dose-response pattern of relationship between FEV1 and serum 25-OHD. However, the relationship did not reach to a statistically significant level. Conclusion: These findings indicated a relationship between serum 25-OHD concentration and FEV1 volume in patients with COPD and suggest optimization of serum vitamin D levels in COPD.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

relationship between serum vitamin d and forced expiratory volume in patients with chronic obstructive pulmonary disease (copd)

background: vitamin d deficiency seems to be associated with pulmonary function deterioration. the present study was designed to investigate the relationship between serum vitamin d and forced expiratory volume in patients with chronic obstructive pulmonary disease (copd). methods: from september 2011 to april 2012 eighty consecutive patients with copd presented to an outpatient clinic of babol...

full text

Serum 25-hydroxy Vitamin D levels in patients with Chronic Obstructive Pulmonary Disease exacerbation: Short Communication

Regarding immune-regulatory roles of vitamin D as well as its effect on Chronic Obstructive Pulmonary Disease (COPD), the present study aimed to evaluate serum vitamin D levels in patients with COPD exacerbation. The study population included 70 patients with COPD exacerbation who were hospitalized in the general ward of an affiliated hospital with Birjand University of Medical Sciences, Birjan...

full text

The Relationship between Serum Uric Acid and Severity of Chronic Obstructive Pulmonary Disease (COPD)

Introduction: Some evidence exists about the possible relationship between the serum uric acid (UA) and exacerbation of the chronic obstructive pulmonary disease (COPD). Present study intended to compare the COPD-related variables and the one-year outcome between the two groups of patients with the high and low UA. Material and Methods: This cohort study consisted of 112 patients with COPD exac...

full text

The Relationship between Diaphragmatic Movements in Sonographic Assessment and Disease Severity in Patients with Stable Chronic Obstructive Pulmonary Disease (COPD)

Introduction: Pulmonary hyperinflation in patients with chronic obstructive pulmonary disease (COPD) can increase the breathing rate and reduce diaphragmatic movements by pushing the diaphragms downward and limiting their movements; this, in fact, can affect the breathing process. The purpose of this study was to compare diaphragmatic movements in COPD patients and healthy ones and to evaluate ...

full text

Vitamin D status and distribution in patients with chronic obstructive pulmonary disease versus healthy controls

 Background: Vitamin D has a potential to modulate inflammatory response against noxious particles in patients with chronic obstructive pulmonary disease (COPD). The present study was conducted to determine the status of serum vitamin D in COPD versus healthy group. Methods: The patients presented to the outpatient pulmonary clinic of Ayatollah Rouhani Hospital, Babol Iran. Diagnosis of...

full text

Vitamin D serum level and chronic obstructive lung disease

Vitamin D serum level and chronic obstructive lung disease

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 3  issue None

pages  451- 455

publication date 2012-01

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023